GI symptoms: the clinical presentation of ulcerative colitis depends on the extent of the disease process. patients usually present with diarrhea mixed with blood and mucus, of gradual onset that persists for an extended period (week).they also may have weight loss and blood on rectal examination.the disease may be accompanied with different degrees of abdominal pain,from mild discomfort to painful bowel movements or painful abdominal ceamping with bowel movements.