LOX-1 is a potent mediator of endothelial dysfunction, induces superoxide generation, and enhances endothelial adhesiveness to leukocytes and chemokine production. In an experimental study of endotoxemic rats, Lands-berger and colleagues evaluated the effects of the adminis tration of anti-LOX-1 by antibodies on intestinal capillary perfusion and leukocyte adhesion by using intravital microscopy.