Lymphatic filariasis is a parasitic disease caused by thread-like worms called Wuchereria bancrofti. The parasite is carried from person to person by mosquitoes. 120 million people are infected in subtropical and tropical Asia (mostly in India), Africa, the Pacific and the Americas (mostly in Brazil, Haiti, Guyana and the Dominican Republic). Lymphatic filariasis is the leading cause of permanent disability worldwide. Out of the 120 million more than 30 % are severely incapacitated by the disease. Over one billion people in over 80 countries are at risk of getting infected.
The life cycle of Wuchereria bancrofti starts, when a male and a female mate inside lymphatic vessels of an infected human. The female releases thousands of microfilariae (prelarval eggs) into the bloodstream. When the host is awake, the microfilariae tend to stay in deep blood vessels. During the sleep they travel near the surface in peripheral blood vessels. This behaviour enables them to get ingested by the night biting mosquito. When ingested by the mosquito, the microfilariae migrate through the wall of the proventriculus and cardiac portion of the midgut eventually reaching the thoracic muscles. Within 1–2 weeks they mature into first-stage larvae and eventually into infective third-stage larvae which migrate through the hemocoel to the mosquito's prosbocis. When the mosquito bites another person, the larvae are injected into the human skin. They migrate to the lymph vessels and mature into adults within six months. Adult females can live up to seven years.
 
Lymphatic filariasis is a parasitic disease caused by thread-like worms called Wuchereria bancrofti. The parasite is carried from person to person by mosquitoes. 120 million people are infected in subtropical and tropical Asia (mostly in India), Africa, the Pacific and the Americas (mostly in Brazil, Haiti, Guyana and the Dominican Republic). Lymphatic filariasis is the leading cause of permanent disability worldwide. Out of the 120 million more than 30 % are severely incapacitated by the disease. Over one billion people in over 80 countries are at risk of getting infected.
The life cycle of Wuchereria bancrofti starts, when a male and a female mate inside lymphatic vessels of an infected human. The female releases thousands of microfilariae (prelarval eggs) into the bloodstream. When the host is awake, the microfilariae tend to stay in deep blood vessels. During the sleep they travel near the surface in peripheral blood vessels. This behaviour enables them to get ingested by the night biting mosquito. When ingested by the mosquito, the microfilariae migrate through the wall of the proventriculus and cardiac portion of the midgut eventually reaching the thoracic muscles. Within 1–2 weeks they mature into first-stage larvae and eventually into infective third-stage larvae which migrate through the hemocoel to the mosquito's prosbocis. When the mosquito bites another person, the larvae are injected into the human skin. They migrate to the lymph vessels and mature into adults within six months. Adult females can live up to seven years.
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