Computational analyses are essential when setting out to validate multiple experimentally proposed interactors, as they can identify the most likely binary or higher order interactions between them and, consequently, assist significantly in target prioritization. Therefore, it was decided to submit the identified DIIIE2-binding candidates to a protein–protein interaction analysis based only on experimentally confirmed interactions. This generated an interaction network comprising 24 (83%) protein nodes with an average number of neighbors of 3.2