Due to its specific role in the organism, the liver is, besides blood,
the main target of Pb-induced oxidative stress. Acute intraperitoneal
(i.p.) administration of 15 mg Pb-acetate/kg b.w. for 7 days
(Mohammadi et al., 2014) and 25 mg Pb-acetate/kg b.w. for 5 days
(Abdou and Hassan, 2014) induced decreases in SOD and CAT activity
and a two-fold decrease in GPx activity. These changes were
followed by a significant decrease in the levels of GSH, partly as a
result of biliary excretion of Pb bound to the —SH groups of GSH,
as proposed by Abdou and Hassan (2014).