The mean blood concentration of tacrolimus in patients with adverse reactions was not different from that in patients
without adverse reactions. We did not find a clear relationship between the blood concentration of tacrolimus and adverse
reactions in this study. It has been reported previously that the blood concentration of tacrolimus correlates closely
to adverse events in renal transplant recipients [9]; higher incidences of adverse events were observed in their patients
with higher tacrolimus blood concentrations (10 ng/ml). The lack of correlation between the blood concentration of
tacrolimus and adverse reactions in this study may be due to the small sample size and/or lower blood concentrations of
tacrolimus.