The demonstration of broad spectrum of antibacterial activity by Tamarindus indica may help to discover new chemical classes of antibiotic substances that could serve as selective agents for infectious disease chemotherapy and control. This investigation has opened up the possibility of the use of this plant in drug development for human consumption possibly for the treatment of gastrointestinal, urinary tract and wound infections and typhoid fever. The effect of this plant on more pathogenic organisms and toxicological investigations and further purification however, needs to be carried out.