In summary, the innate immune system is encoded to distinguish biochemical differences between Gram-positive and Gram-negative bacteria. In particular, the laboratory of Jie-Oh Lee has provided clear evidence that TLR2 has 20/20 vision for lipoproteins, the heterodimerization of TLR2-TLR1 and TLR2-TLR6 heterodimers forms different lipid-binding pockets that distinguish triacylated from diacylated lipopeptides