In this first proof-of-concept study, we directly analyzed 32 drug
reference substances and 74 street drug samples by using MALDI
HRMS full scan.Wewere able to identify 49 substances thatwere structurally
confirmed by tandem mass spectrometry (MS/MS) experiments.
Furthermore, we evaluated the potential benefit of ionic liquid MALDI
matrices to acquire also quantitative information with MALDI MS.