Dextromethorphan (Robitussin) is a non-prescription drug used to treat cough associated with upper respiratory infections (URIs). However, it has not been shown to improve cough or sleep quality in children, and is not recommended by the American Academy of Pediatrics or the American College of Chest Physicians for use in this age group. Honey is cited by the World Health Organization as being potentially effective in controlling cough in children. It also is used in many cultures worldwide to treat URI symptoms; however, controlled trials examining this are lacking. Paul and colleagues examined the effects of a single dose of honey or honey-flavored dextromethorphan versus no treatment in children with nocturnal cough from URIs, and its associated sleep difficulties.