n overweight and obese subjects perceiving a significant amount of breathlessness during exercise, 1 month of RMET before the start of the 3-month supervised EN intervention, reduced breathlessness during exertion and increased running performance more than EN alone. Reduced breathlessness was associated with increased daily physical activity and daily energy expenditure. The change in lifestyle (increased activity and reduced energy intake) improved the blood lipid profile in subjects with pathologic values at the beginning of the study. The benefits of the supervised period could be preserved independent of the training regime and despite decreased compliance in both groups. Therefore, RMET can be recommended before the start of a lifestyle intervention in overweight and obese subjects to enhance benefits of physical fitness.