Azoxystrobin did not provide adequate control in Fall 2001. This is a disturbing outcome. Strobilurin fungicides with this specific and limited biochemical mode of action might be expected to be prone to development of resistance. In all three experiments, target spot epidemics were initiated by ingress of natural inoculum, probably from commercial tomato farms in the Ft. Pierce vicinity. It may be that one of these natural populations in Fall 2001 contained a variant isolate or isolates resistant to azoxystrobin. Isolates of Didymella bryoniae (Auersw.) Rehm, causal agent of gummy stem blight of cucurbits, have recently been shown to be resistant to azoxystrobin after limited use (STEVENSON et al. 2002).