NoncanonicalWNT signals are transduced through Frizzled family receptors and
ROR2/RYK coreceptors to the Dishevelled-dependent (Rho family GTPases and c-jun NH2-
terminal kinase) or the Ca2+-dependent (NLK and nuclear factor of activated Tcells) signaling
cascades.WNT signals are context-dependently transduced to both pathways based on the
expression profile ofWNT, SFRP,WIF, DKK, Frizzled receptors, coreceptors, and the activity of
intracellularWNT signaling regulators.