The applicability, accuracy, precision, sensitivity of the proposed method havebeen demonstrated based on SANCO/12571/2013 European Guidelines. LODs were below the MRLs set by the European Union for all compounds studied. Considering that Fe3O4@SiO2@C18 nanoparticles inherit the virtues of being easy-to-prepare, cost-effectiveness and ease of separation and dispersion, this protocol is believed to be promising for the screening of the selected compounds in milk matrices.