The new treatment of chronic hepatitis C (CH-C), a prominent devastating liver disease worldwide, is evolving and potentially and promises higher cure rates with fewer side effects and shorter treatment duration recently, a triple therapy (TT) combination of the drugs which included pegylated interferon alfa (PEG-IFN), ribavirin (RBV) and the first generation protease inhibitors [telaprevir (TVR) and boceprevir (BOC)] was the stan- dard of care for treating chronic hepatitis C (CH-C) [2]. However, in late 2013, two new regimens were approved. The first regimen included sofosbuvir (SOF)which was given in combination with rib avirin with or without pegylated interferon. The second regimen triple combination of simeprevir, pegylated interferon