In 1999, the Centers for Disease Control and Prevention provided comprehensive
estimates of foodborne illnesses, hospitalizations, and deaths in the United States caused by
known and unknown agents (3). This effort identified many data gaps and methodologic
limitations. Since then, new data and methods have become available. This article is 1 of 2
reporting new estimates of foodborne diseases acquired in the United States (hereafter referred to
as domestically acquired). This article provides estimates of major known pathogens; the other
provides estimates for agents of acute gastroenteritis not specified in this article (4).