It is reasonable to hypothesize that the reduction of estradiol and progesterone levels in serum is directly related to the impairment of ovarian subcellular organelles, such as mitochondria,endoplasmic reticulum, and Golgi complex where endogenous estradiol and progesterone were synthesized., Human studies indicates that athletes should follow diet and exercise regimens that provide energy of 30-45 kcal/kg/day fat free mass while training involving body weight control.