Skin lesion scores for the 5 experimental groups are shown in Fig. 5. Most infected skin lesions showed similar well-defined redness and scaling on Day 1. On Day 8, the scores of the 1% and 5% COSgroups and the FCZ group were lower than that of the MC group. The decrease in the score of the 5% COS group was significant (p < 0.05).On Day 15, the scores of the 5% COS group and the FCZ group werehighly significantly decreased (p < 0.01) in comparison with the MC group. These findings indicate the striking, dose-dependent antidermatophytic activity of COS and suggest its potential for clinical development.