An updated American Diabetes Association/European Association for the Study of Diabetes position statement (15) evaluated the data and developed recommendations, including advantages and disadvantages, for antihyperglycemic agents for type 2 diabetic patients. A patient-centered approach is stressed, including patient preferences, cost and potential side effects of each class, effects on body weight, and hypoglycemia risk. Lifestyle modifications that improve health (see Section 4. Foundations of Care) should be emphasized along with any pharmacological therapy.