While this indicates such probes do not report on the accessible
Zn2+ pool, it suggests they may have an unintended use in
examining the proteome. It is becoming increasing clear that
within the complex environment of the cell, probes can be
involved in interactions that are difficult to predict based on the
conditions used for in vitro biochemical characterization.
Similar studies on other small-molecule probes have not been
reported, but it is possible that other probes interact with
cellular components