12.6. VD in OA and degenerative disc disease
There is a small but statistically significant clinical benefit to
VD treatment in patients with Knee OA.153 VD deficiency is
greatly associated with early stage of OA, suggesting VD
supplementation before cartilage damage occur.154 Several
clinical trial have ensued and are ongoing. These studies are in
the initial stage, and to date no strong evidence has been
available establish the role of vitamin D in OA. There is also
some evidence of association with degenerative disc disease
with VD deficiency.155,156