Some investigators have proposed that increased fructose con-
sumption may be related to the current epidemics of obesity and
metabolic syndrome (1– 4). The purpose of this article is to re-
view some of our recent work investigating 2 hypotheses: 1)
fructose consumption promotes a state of positive energy bal-
ance, and 2) fructose consumption favors the development of an
atherogenic lipoprotein profile.