ROC curves describe the sensitivity and specificity of ESAT-6
and CFP-10 responses compared with high M tuberculosis
exposure (>4) (fig 4). T-SPOT.TB ESAT-6 responses appeared
to offer the highest sensitivity and specificity of any single
antigen (area under the curve (AUC)=0.933). T-SPOT.TB CFP-
10 individual responses were less sensitive and specific
(AUC=0.687). The combined ESAT-6 CFP-10 T-SPOT.TB
response appeared to be largely influenced by the ESAT-6
component. The sensitivity and specificity of the QTF ESAT-6
and CFP-10 responses (AUC) were 0.721 and 0.825, respectively.