The purpose of this study was to (i) identify sociodemographic, environmental and disease prevention indicators associated with P. falciparum infection prevalence and (ii) produce a smooth risk map of P. falciparum infection among school-aged children for Côte d’Ivoire. To our knowledge, this spatial analysis is the first at the national level based on P. falciparum data collected within a few weeks during the dry season in late 2011/early 2012. The results obtained from this spatially explicit analysis are useful for current and future malaria control efforts in Côte d’Ivoire.