L.R. is supported by the European Commission's sixth 6. Framework Programme (Contract No. LSHC-CT-2006 037777). A.P is supported by St. Christopher's Hospice. M.H. are Principal Investigators for the CoMPASS collabora- tive (the UK National Cancer Research Institute supportive and Palliative Care Research Collaborative). M.H. is sup- ported by the NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley Foundation Trust and Institute of Psychiatry, King's College London and is a NIHR Senior Investigator