Combined use of antitussives (cough‐relieving agents) with N‐acetylcysteine may cause a dangerous
secretory congestion due to the reduced cough reflex.
Oral antibiotics should be administered separately and at an interval of at least 2 hours. (In vitro
experiments report an inactivation of antibiotics (tetracycline, aminoglycosides, penicillins) due to
acetylcysteine when relevant substances were directly mixed.)