New design material based on ketoenol–pyridine-immobilized silica was fabricated for quantitative removal of Zinc. Analysis of surface chemistry was evaluated using BET, BJH, EA, FT-IR, 13C NMR, SEM and XRD. TGA was also used to certify the good chemical and thermal stability of the new surface. Adsorption studies have demonstrated the ability to highlight the surface designed for quantitative and selective removal of Zn(II) from aqueous solutions and real samples using ICP-AES.