Table 1 depicts characteristics of trials included in this meta-analysis. We found 13 separate randomized, double-blind, placebo-controlled trials involving 731 participants that compared omega-3 FAs to placebo for the treatment of depressive disorders. Four
studies reported a significant benefit of omega-3 fatty acids in the treatment of
depression and 9 studies reported no significant difference of omega-3 fatty acids compared to placebo. No studies reported a worsening of depressive symptoms with omega-3
fatty acid therapy compared to placebo.