Based on this study, we speculate that low vitamin D levels may
lead to impaired wound healing in pediatric burn population,
adults with large burns, and patients with chronic non-healing
ulcers. There would appear to be an important balance between
vitamin D and TGFb1 levels, where high vitamin D levels in
concert with low TGFb1 levels improve wound healing, whereas
high vitamin D levels in concert with high TGFb1 levels reduce
fibrosis. This suggests that vitamin D modulates the wound
healing effects of TGFb1 differentially, depending on the TGFb1
concentration and underlying wound healing state, whether
this is impaired wound healing or fibrosis. Therefore, vitamin D
supplementation may be an effective therapy for improving
wound healing and also reducing fibrosis, a finding that is
certainly worthy of further investigation.
Based on this study, we speculate that low vitamin D levels maylead to impaired wound healing in pediatric burn population,adults with large burns, and patients with chronic non-healingulcers. There would appear to be an important balance betweenvitamin D and TGFb1 levels, where high vitamin D levels inconcert with low TGFb1 levels improve wound healing, whereashigh vitamin D levels in concert with high TGFb1 levels reducefibrosis. This suggests that vitamin D modulates the woundhealing effects of TGFb1 differentially, depending on the TGFb1concentration and underlying wound healing state, whetherthis is impaired wound healing or fibrosis. Therefore, vitamin Dsupplementation may be an effective therapy for improvingwound healing and also reducing fibrosis, a finding that iscertainly worthy of further investigation.
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