The aim of the present study was to evaluate the hypoglycemic activity of Morus alba extract from different grades of alcohol and to know which grade is
a potent inhibitor of a- amylase and a- glucosidase enzymes. The screening of plant extracts of different grades was based on in vitro inhibition of a-
amylase and a- glucosidase enzymes. All extracts were subjected to enzyme inhibitory assay by using different concentrations of extracts. The a-
glucosidase inhibitory activity was higher in 60% alcohol extract with a percentage inhibition of 80.92±2.39 and an IC 50 value of 0.4113, the lowest was
found in 100% alcohol extract 30±0.7 % and IC 50 value 0.6315. The 60% alcohol extract at 1mg/ml had an inhibition of 69.69±0.85% for salivary amylase
and 78.77±0.75% for pancreatic amylase with IC50 value of 0.4594 and 0.482 respectively. The lowest inhibition was found in 100% alcohol extract
16.58±0.13, and 22.39±0.13% respectively. These results suggest that 60% alcoholic extract of Morus alba is a potent inhibitor of a- amylase and a-
glucosidase enzymes, therefore it may help in reducing post-prandial absorption of carbohydrates from the intestine.