Seasonality of H. pylori infection is another possible
factor which may affect PUD onset. Savarino et al. [26],
however, did not find any difference in the percentage of
H. pylori-positive DU cases between seasons or a parallel
annual fluctuation in gastric acidity and H. pylori infection.
These findings are in line with another study showing
no significant correlation between the seasonal
differences in the diagnosis of ulcer disease and presence
of H. pylori infection [47].