Applephenon inhibits glucosyltransferase (GTF) of S. mutans that has an activity of dental plaque formation, and IC50 is about 120 mg/ml.
Main component of Applephenon for the activity is a procyanidin fraction.
Applephenon is not have much strong activity of a-amylase.
The inhibitory effects of Applephenon is much strong (20 times) than the effects of EGCg, main polyphenol in green tea extract.
On clinical test (n=20), mouse rinse (500 mg/ml of Applephenon solution) inhibits on dental plaque formation significantly.