In the incision model, the mice were anesthetized by administering ketamine (0.5 ml/kg b.w. i.p.) and one longitudinal peravertebral incision of about 2 cm length was made through the skin and cutaneous muscle at a distance about 1.5 cm from the midline on the each side of the depilated back of the mice 30 minutes later the administration of ketamine injection. After the incision, the parted skin was sutured 1cm apart. The wounds of animals in the differentgroups were treated with topical application of the ointments once a day. The sutures were removed on the 9th day after wounding and the breaking strength was measured on the 10th day. Tensile strength was calculated using the following formula: Tensile strength = Breaking strength (g)/ cross-sectional area of skin (mm2)