a-Methyldopa (a centrally acting a-adrenergic agonist that
inhibits vasoconstricting impulses from the medulla
oblongata) has traditionally been the most commonly used
agent for the control of blood pressure during pregnancy,
particularly in those with chronic hypertension. Its safety
has been well established both in pregnancy and in the
long-term follow-up of the infants. One of the most
frequent side effects is sedation, which can be profound.
This is often poorly tolerated and leads to unpredictable