In presence of growth stimulus, adult cells residing in Go phase enters the G1 phase in presence of Cdk4/6 + Cyclin D (upregulated c-Myc). It also stimulates Cyclin E synthesis which in presence of Cdk2 helps the entry of the cells from G1 to S phase. Further Cdk2 binds to Cyclin A for metaphase of mitosis stage that is promoted by Cdk1 + Cyclin B. * indicates target of interest for this study.