Most of the mammalian HA are found in the skin
where it serves as a matrix. HA is essential for maintaining
the normal structure of the stratum corneum and
conserve epidermal barrier functions. HA also plays a series
of other important roles in the skin, for example, in
immobilizing water in tissue, and influencing cell proliferation,
differentiation and tissue repair. Due to a high
water binding capacity, HA often contributes to the
maintenance of the extracellular dermal matrix and
facilitates the transport of water-soluble molecules and
ion solutes.