Key Study Factors
The inclusion criteria included the following: human studies comparing
pit-and-fissure sealants with fluoride varnish in caries prevention on occlu-
sal surfaces of molars and premolars; in children and adolescents; and with
randomized (parallel group or split-mouth) or quasi-randomized con-
trolled trials. Comparisons allowed were sealant versus fluoride varnish
or sealant with fluoride varnish versus varnish alone.