Minimum inhibitory concentrations (MIC) of new antibiotics A4 and A5 produced
by SA198 strain.
The antimicrobial activity of compounds A4 and A5 is shown in Table 4. A4 and A5 showed high activity against fungi such as M. ramannianus (MIC: 5–1gml−1), A. carbonarius (MIC:
10–2gml−1) and P. expansum (MIC: 2–2gml−1). Moderate activity was also recorded against other filamentous fungi such as A. fabae, F. culmorum and F. equiseti (MIC: 40–10gml−1) as well
as Gram-negative bacteria (E. coli, K. pneumoniae and P. aeruginosa)
and Gram-positive bacteria (B. subtilis, E. faecalis and L. monocytogenes).
However, the two yeast strains (C. albicans and S. cerevisiae)
have shown resistance (MIC: >100). The activity of A5 was more
potent than that of A4.