We also demonstrated that punicalagins directly inhibit melanin production in Melan-a cell cultures and was not a result of hydrolysis of punicalagins to ellagic acid [27].
Since pomegranate fruit extract enriched with 20% punicalagin and chia seed extract high in PUFAs reduces melanin production through different mechanisms, we hypothesized that a combination of the two extracts may exhibit stronger efficacy in reducingmelanin content than either extract alone.