Healthcare systems are facing tumultuous, challenging times that are likely to become the new normal. As a crucial part of the healthcare team, the nurse leaders of today are faced with ever-increasing responsibilities; higher levels of accountability; and multiple, ongoing stressors that can have a daily, detrimental impact on a leader's ability to succeed, let alone survive. In response to these challenges, the nurse leader needs to develop and sustain a significant capacity of resilience to thrive and succeed as a transformational leader within the profession of nursing.The purpose of this article is to provide current and future nurse leaders with new insights into developing and maintaining personal and professional resilience in the face of perpetual challenges and continual change. Although various concepts and characteristics have been described within the construct of resilience, this article proposes and describes the importance of the relationship between the concepts of equanimity, optimism, and perseverance, and how the three assemble to create a paradigm that may be foundational to resiliency in today's nurse leaders.