Over a period of about 50 years the structure and function of bovine pancreatic ribonuclease A (RNase A; EC 3.1.27.5) have been extensively studied .
RNase A is a small, 124 residue protein that is still widely used as a model system to develop new methodologies, as well as to investigate various protein features including mechanism of kinetic reactions, unfolding process and structure–stability relationships