a protein kinase involved in cellular and organismal growth responses to nutrient availability. We also now recognize links between aberrant lysosomal function and several diseases, including lysosomal storage diseases and neurodegenerative disorders , and also with aging. On page 83 of this issue, Folick et al. indicate how lysosomes play a role in the latter—by deploying a lipid molecule to the nucleus, whose impact on gene expression extends life span in an animal model (the nematode Caenorhabditis elegans). The study not only uncovers a lysosome-to-nucleus signaling pathway but also highlights the potential of lipids in mediating long-range physiological effects.