In the present study we aimed at unraveling the spatio-temporal
dynamics of memory-trace formation by assessing the anatomical
areas underlying RS and RE during stimulus repetition using magnetoencephalography
(MEG). To our knowledge, this is the rst attempt to
localize the neural substrates of human auditory stimulus repetition at
different time intervals. This might help understanding whether RP is
generated in one specic brain area or whether it is a non-unitary
phenomenon accounted for by the modulation of hierarchically
organized processing stages devoted to the encoding of different levels
of acoustic regularity. Furthermore, it has been hypothesized that
frontal and parietal connections with auditory cortices might be been hypothesized that
frontal and parietal connections with auditory cortices might be
involved during repetition suppression (Baldeweg,an idea
supported by “predictive coding”.which explains part of the top-down adjustment occurring
during perceptual learning. So far, the involvement of non-auditory
neuronal sources in the generation of repetition effects like the RP has
been scarcely studied, and only indirect evidence is provided from
EEG studies and anatomical
findings. Here,we expected to nd amodulation
of different anatomical generators activated at different time intervals,
supportive of a non-unitary phenomenon reecting the encoding of
different aspects of the acoustic information at different stages. In addition
to RS, we expected to clarify the involvement of RE as indexing
memory-trace formation. Finally, we hypothesized that non-auditory
areas would participate in the encoding of stimulus-specic memory
traces, thus extending the notion that acoustic memory-trace formation
is driven by plastic changes that extend beyond the auditory cortex.
In the present study we aimed at unraveling the spatio-temporaldynamics of memory-trace formation by assessing the anatomicalareas underlying RS and RE during stimulus repetition using magnetoencephalography(MEG). To our knowledge, this is the rst attempt tolocalize the neural substrates of human auditory stimulus repetition atdifferent time intervals. This might help understanding whether RP isgenerated in one specic brain area or whether it is a non-unitaryphenomenon accounted for by the modulation of hierarchicallyorganized processing stages devoted to the encoding of different levelsof acoustic regularity. Furthermore, it has been hypothesized thatfrontal and parietal connections with auditory cortices might be been hypothesized thatfrontal and parietal connections with auditory cortices might beinvolved during repetition suppression (Baldeweg,an ideasupported by “predictive coding”.which explains part of the top-down adjustment occurringduring perceptual learning. So far, the involvement of non-auditoryneuronal sources in the generation of repetition effects like the RP hasbeen scarcely studied, and only indirect evidence is provided fromEEG studies and anatomicalfindings. Here,we expected to nd amodulationof different anatomical generators activated at different time intervals,supportive of a non-unitary phenomenon reecting the encoding ofdifferent aspects of the acoustic information at different stages. In additionto RS, we expected to clarify the involvement of RE as indexingmemory-trace formation. Finally, we hypothesized that non-auditoryareas would participate in the encoding of stimulus-specic memorytraces, thus extending the notion that acoustic memory-trace formationis driven by plastic changes that extend beyond the auditory cortex.
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