The P388 cells are growing exponentially from day 3 to day 4 with a doubling time (TD) of 10 h, where after growth restriction is seen. Mean survival time of the animals was 12 days (range 8-18 days). The L1210 cells are growing exponentially from day 6 to day 9 with a doubling time of about 22 h. After day 9 growth retardation occurs with a net loss of cells from day 12 through day 14. Mean survival time 34 days (range 22-49 days).