Ion chromatography is basically a chromatographic method that has become a routine analytical method. It is regarded as a versatile analytical technique for separating and quantifying ions. The concept of Ion chromatography was successively widened with advancements of the rapid development in separation, column stationary phase, great variety of detectors, data analysis and hyphenated techniques. Moreover, it could include other separation methods (e.g., ion interaction and ion exclusion) for simultaneous separation of analyst components. Ion chromatography analysis has matured to a well-established rugged, sensitive and reliable analysis technique for a wide variety of chemical compounds present in various matrices. On this manner, many papers have been published during the last few years dealing with new modalities in sample pretreatment, separation, detection, etc., for improving samples analysis. The following section deals with the recent development in instrumentations and applications to fit the desired fields of applications.