Main results
Seven trials were eligible for inclusion, comprising a total of 347 participants. Five trials in people with acute wounds evaluated the
effects of Aloe vera on burns, haemorrhoidectomy patients and skin biopsies. Aloe veramucilage did not increase burn healing compared
with silver sulfadiazine (risk ratio (RR) 1.41, 95% confidence interval (CI) 0.70 to 2.85). A reduction in healing time with Aloe vera
was noted after haemorrhoidectomy (RR 16.33 days, 95% CI 3.46 to 77.15) and there was no difference in the proportion of patients completely healed at follow up after skin biopsies. In people with chronic wounds, one trial found no statistically significant difference
in pressure ulcer healing with Aloe vera (RR 0.10, 95% CI -1.59 to 1.79) and in a trial of surgical wounds healing by secondary
intention Aloe vera significantly delayed healing (mean difference 30 days, 95% CI 7.59 to 52.41). Clinical heterogeneity precluded
meta-analysis. The poor quality of the included trials indicates that the trial results must be viewed with extreme caution as they have
a high risk of bias.
Main resultsSeven trials were eligible for inclusion, comprising a total of 347 participants. Five trials in people with acute wounds evaluated theeffects of Aloe vera on burns, haemorrhoidectomy patients and skin biopsies. Aloe veramucilage did not increase burn healing comparedwith silver sulfadiazine (risk ratio (RR) 1.41, 95% confidence interval (CI) 0.70 to 2.85). A reduction in healing time with Aloe verawas noted after haemorrhoidectomy (RR 16.33 days, 95% CI 3.46 to 77.15) and there was no difference in the proportion of patients completely healed at follow up after skin biopsies. In people with chronic wounds, one trial found no statistically significant differencein pressure ulcer healing with Aloe vera (RR 0.10, 95% CI -1.59 to 1.79) and in a trial of surgical wounds healing by secondaryintention Aloe vera significantly delayed healing (mean difference 30 days, 95% CI 7.59 to 52.41). Clinical heterogeneity precludedmeta-analysis. The poor quality of the included trials indicates that the trial results must be viewed with extreme caution as they havea high risk of bias.
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