Given that the production of high quality red wines demands theexploitation of the intrinsic chromatic characteristics of the grapes andtheir preservation in thefinal product, the aim of this work was to eval-uate the effect of an enzyme preparation used at two different doses onthekineticsandextentoftheanthocyaninextractionduringmacerationand to relate this effect with the skin softening of two red wine grapecultivars. In particular,Vitis viniferaL. cv. Cabernet Sauvignon andNebbiolo were selected on the basis of their different anthocyanincontent and profile mainly composed of tri- and disubstituted anthocy-anins, respectively. The two varieties are widely used to produce highquality red wines that are commercialized in worldwide.