This study revealed the efficacy for wrinkles and tolerability of a cosmetic containing niacinamide, SSTT, in Japanese women. Overall, 64% of subjects who used the test substances showed marked or moderate improvement with the combination of observation and photographs based on the guideline of the JCIA.5 No subjects who used the control showed marked or moderate improvement. Significant reduction of wrinkle grades was seen both in the tested and control areas as compared with preapplication. Significant reduction of wrinkle grades in the tested area was seen as compared with the control