Antibiotic Therapy in PPROM With the strong link between infection and PPROM, research has focused on the use of antibiotics following PPROM for the purpose of decreasing the complications associatedwithinfection.Antibiotictherapycouldimprove outcome in two ways. First, the prevention or treatment of infection may reduce maternal or fetal/neonatalmorbidity. Second, bytreatingor preventingascendinginfection,antibiotic therapy may prolong pregnancy and delay the progression to preterm birth.7,9