Conclusions
It can be predicted that the difficulties in the fruiting-body cultivation of A. cinnamomea would not be solved easily. In order to obtain bioactive components, the mycelial production by submerged culture thus deserves to be studied. Due to the fact that A. cinnamomea has been considered to have a characteristic of growing slowly, the modification of media composition or the control of environmental conditions would be vital to enhance the production efficiency. According to the RSM, the medium composition was modified and the mycelium concentration of A. cinnamomea reached to 2164.2 mg/100 ml at the 7th day and the biomass productivity had a eightfold increase, compared to the growth in basal medium. The results proved that the production rate of mycelium of A. cinnamomea could be highly enhanced by means of the control of cultural conditions and the modification of medium composition based on the RSM.